OPTIMIZATIONANTIBACTERIAL OINTMENT FORMULAPEG400 AND PEG4000BASEOFMANGOSTEEN PEEL (GarciniamangostanaLinn) ETHANOLIC EXTRACTWITH DESIGNFACTORIAL METHOD

Wednesday, January 10, 2018

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Mangosteenpeel has benefit as anantioxidant, as well as anantibacterial. Compoundsthathaveantibacterialactivity is α-mangostin. In order tomakeiteasytheusedandeffectiveness of antibacterial, mangosteenpeelextractneedstomade asointments. Thisstudypurposetodeterminetheeffect of thecombination of PEG 400 and PEG 4000base on thephysicalcharacteristicandantibacterialagainstStaphylococcus aureusas well as getthe optimum formula.Ointments were made into four formulas that have low level 26 g andhigh level 32 g of PEG 400, low level 30 g andhigh level 37 g of PEG 4000withfactorialdesignmethod. FormulaoptimizationusingDesignExpertsoftwarewiththeparameters of thephysicalcharacteristic of ointmentandantibacterialactivity. Factorialdesignpredictedresultsverifieandanalyzed byt-testLSDwith95% confidence level. The optimumcombination ofPEG400andPEG4000 incomparisonof 30,7gand33gin 100g ofointment. Comparison ofpredictionandverificationshowedsignificant differencesin testing parameterspHand notsignificantlydifferentindispersivepower, adhesion,viscosityandantibacterial. Optimal ointmentwith a semi-solidform, pH 4,17, viscosity98,33d.Pas, adhesion 17,33seconds, dispersivepower10,36 cm2 andinhibition zone diameter of 11 mm.

Keywords: ointments, mangosteenpeel, PEG 400, PEG 4000, antibacterial, factorialdesign

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